A peek into coronavirus phylogeny
- davidmhenke
- Sep 24, 2020
- 1 min read
Updated: Jan 4, 2025
Investigation into the SARS-CoV 2 & related coronavirus spike proteins. A sequence based viewpoint.
https://www.nih.gov/news-events/nih-research-matters/novel-coronavirus-structure-reveals-targets-vaccines-treatments
Historic CoV structures and receptors
(prior to SARS-CoV-2)
Shared receptors across genogroups
Receptors do not determine severity of disease
SARS-CoV 1
Similar to SARS-CoV 2
+ssRNA genome
Genome length ~29.7k NT
Polyadenylated
Spike protein (S) binding target: ACE2
Complicated transcriptome structure: initiation for transcription dependent on the 5’ leader sequence ( c )
Phylogenetic Investigation
Reference strains for phylogenetic reconstruction
WARNIGN: Dendrograms to follow...
BCM SARS-CoV-2 Isolates
Nine isolates from healthcare workers
All viral genomes were unique
Of nine Spike proteins, 5 unique sequences
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